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Obama and pledged she and McCain would work for the middle-class.
She frequently displayed the folksy style that has become a favorite target of late-night comics. "Aw, say it ain't so, Joe," she told Biden at one point, adding a "doggone it" for good measure.
Biden, 65, a veteran foreign policy expert, had one emotional moment, choking up when recalling having to raise his two young sons alone after their mother died in a car crash.
As the two strode on the stage, Palin greeted Biden, saying: "Nice to meet you. Can I call you Joe?"
The debate came as Obama solidified his lead in national polls and gained an edge in crucial battleground states as the Wall Street crisis spread.
Biden and Palin said they would work to change current U.S. economic policy to make it more friendly to middle-class workers, but Biden noted McCain had called the fundamentals of the economy strong as the Wall Street crisis broke out.
"That doesn't make John McCain a bad guy, but it does point out he's out of touch," Biden, a Delaware senator, said in the debate on the campus of Washington University in St. Louis, Missouri.
Palin said McCain had been talking about the American workforce and said Obama would raise taxes on American workers and small business owners. Obama in fact has called for a middle-class tax cut and would raise taxes only on those making more than $250,000.
'SOMETHING NEW'
"I do respect your years in the U.S. Senate, but I think Americans are craving something new and different," Palin told Biden.Biden pledged he and Obama would end the war. Obama is an early critic of the Iraq war who has called for a 16-month timeline to withdraw U.S. troops. "Your plan is a white flag of surrender," Palin told Biden.The highly anticipated match-up promised more than the usual drama because of curiosity about Palin, a relative unknown who was thrust into instant celebrity when she was selected as McCain's No. 2 in August.The encounter may have drawn a larger television audience than the 52 million who watched last week's first debate between the presidential candidates.Biden said the $700 billion bailout of Wall Street he voted for, along with Obama and McCain, might force the Democrats to reconsider their promise to double foreign aid."The one thing we might have to slow down is a commitment we made to double foreign assistance," he said when asked what programs might have to be jettisoned because of the financial crisis.Palin said there was nothing she and McCain would have to forego. "There hasn't been awhole lot that I've promised, except to do what is right for the American people," she said. "I don't believe that John McCain has made any promise that he would not be able to keep, either."
Palin's lack of national experience and her hesitant performance in rare media interviews had raised doubts about her readiness and prompted criticism even from some prominent conservatives.
But she said her experience as a governor and as a mayor of tiny Wasilla, Alaska, was her strength as a candidate for vice president. She frequently said she and McCain were a team of mavericks who could change Washington.
"John McCain has been the consummate maverick," she said. "Barack Obama, of course, he's pretty much only voted along his party lines."
Biden said McCain had not been a maverick on the vital issues facing the United States from health care to Iraq. "He's not been a maverick on virtually anything that people talk about around the kitchen table," he said.