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He rose to managing director in 1997, and vice chairman in 2004.
Among his biggest deals, MacDonald advised Imperial Tobacco on its $19 billion acquisition of Altadis, the Swedish government on the sale of Absolut vodka maker Vin & Sprit, and Reuters on its merger with Thomson.
A keen rugby fan, MacDonald played for Cambridge while at the university. Last year he hired a 10-seat private jet so he and clients could avoid traffic problems en route to the Rugby World Cup final in Paris, according to the Press Association.
In the year to December 4, Morgan Stanley advised on $556 billion of announced mergers worldwide, making it the world's no. 5 merger adviser, according to Thomson Reuters data.
Its market share slipped to 19.4 percent this year, from 28.9 percent a year ago, as concerns about the standalone investment banking model forced it and peer Goldman Sachs to convert to Federal Reserve-regulated bank holding companies.